The neural cell adhesion molecule (N‐CAM) is believed to be a key regulator of adhesive events in the nervous system and skeletal muscle. The recent isolation of N‐CAM cDNAs from different tissues has identified a high degree of diversity in primary amino acid sequence between different isoforms. In this article, we review these recent studies and discuss methods for unravelling the functional consequences of the generation of multiple N‐CAM polypeptides using gene transfection approaches.

The paper begins with an overview of the historical roots of philosophical hermeneutics grounded in the work of Husserl and Heidegger. It goes on to explore the philosophical hermeneutics of Hans Georg Gadamer as a philosophy useful to nursing research. The four concepts of prejudice, the fusion of horizons, the hermeneutic circle and play are discussed, as are the implications these concepts have for nursing research. These concepts have been utilized in the author's own research and examples from this research (...) are given to illuminate how these concepts can be shaped to the purposes of nursing research. While the concepts discussed stem from the work of Gadamer, the ways they have been utilized by the author do not represent a Gadamerian method. Gadamer's project is purely philosophical. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Søren Kierkegaard and the Word(s): Essays on Hermeneutics and CommunicationGeorge ConnellPoul Houe and Gordon D. Marino. editors. Søren Kierkegaard and the Word(s): Essays on Hermeneutics and Communication. Copenhagen: C. A. Reitzel, 2003. Pp. 299. Paper, kr. 375,–Though many associate Kierkegaard with isolated individuality, Kierkegaard scholars are rather gregarious. Four times since 1985, Kierkegaard devotees from all the inhabited continents have gathered at St. Olaf College for several days (...) of intense paper reading. Since it is difficult to keep a handle on so much material presented orally and because many were not able to attend, it is a commendable service that Houe and Marino have edited and published many of the papers delivered at the 2001 conference, just as they had previously published essays from 1998 conference and C. Stephen Evans and I had published essays from the 1989 conference.This volume reflects its origins in several ways. First, the essays are unusually brief compared to most journal articles (around ten pages each). While this is an agreeable format when listening to many papers in a single day, I do think that many of these essays are rather rushed and less than fully developed. Accordingly, the reader of these essays may well feel stimulated by interpretive suggestions rather than satisfied by thoroughly worked out treatments.Second, the essays are quite diverse, as conference papers tend to be, even when, as in this case, a preferred theme—hermeneutics and communication—was stated in advance. Since, as Alastair Hannay notes in the opening keynote essay, "hermeneutics" is used in a wide variety of ways, this theme really did not limit participants to any significant degree. Essays in this volume look variously at Kierkegaard's practice of hermeneutics (especially in reference to the Bible), at our predicament of interpreting Kierkegaard's notoriously elusive and cryptic pseudonymous works, at hermeneutics as our existential disposition as sense-making creature thrust into an ambiguous world, at hermeneutics as a quasi-Hegelian project of engulfing particularity without remainder in a totalizing whole, and, in contrast, at radical hermeneutics (a term coined by John Caputo and applied to Kierkegaard) as an interpretive approach that refuses the consolations and consonances of its Gadamerian cousin. As the use of "hermeneutics" varies, we hear that Kierkegaard is both an exemplary hermeneuticist and "the ultimate non-hermeneuticist." And in a number of essays, the issue of hermeneutics only seems to come up in the vacuous sense that the author offers a reading of some Kierkegaardian text or texts.The wide variety of essays included here reflects itself in the unsatisfactory final article in which Poul Houe makes a thoroughly desultory attempt at pulling the various articles together. I've tried my hand at writing such a piece, so I feel empathy for Houe's plight. But the paragraph per essay tour of the book is so hurried and so perfunctory that I wonder what purpose it really serves in this case.Though widely varying in topic and approach, most of the essays in the volume are quite good, if tantalizingly short. Given that there are twenty-five essays in the volume, it is not possible to summarize them here. But several observations are in order. First, it is especially nice to see five essays by Danish scholars included in this book. The community of Kierkegaard scholars has increasingly come to appreciate that viewing him in terms of his local context can be quite illuminating. American scholars have done excellent work along these lines, but clearly Danes have a crucial role to play in this interpretive task. Second, there have been heated disagreements in Kierkegaard circles over how to place Kierkegaard in reference to philosophical postmodernism. That polemic is in evidence in this volume as well. Several essays, most notably that of David Goicoechea, affiliate [End Page 502] Kierkegaard with postmodernist refusals of the totalizing understandings. In contrast, Sylvia Walsh juxtaposes Kierkegaard's "erotic hermeneutics," which treats its phenomenon with amorous tenderness, with Derrida's deconstructive approach to interpretation, which Walsh sees as a violent expression of the will to power. Christopher Simpson tries to reconcile these divisions by reading Kierkegaardian faith as an attractive... (shrink)

R. Kevin Hill argues that while Walsh is correct in urging caution regarding Rand's polemical characterizations of Kant, interpreting her charitably reveals surprising insights into the underlying structure of Kant's thought. Rand's objections to Kant's epistemology, psychology and metaphysics are truer to Kant's intentions than revisionist attempts to save him from himself. Her objections to Kantian ethics contain promising critiques of both Kant's rational reconstructive-methodology and his misuse of the concept of agent-neutral reasons. Lastly, though she paints too broadly (...) in her account of Kant's influence, two questionable tendencies in contemporary thought are traceable to him. (shrink)

Central-state materialism is a very strong, but also very exciting theory of mind according to which each mental state is identical with a state of the central nervous system. CSM thus goes considerably beyond early versions of the identity theory of mind, since those early accounts held only that sensations are to be identified with neural events. CSM, by contrast, is a thesis about all mental states; every mental state is held to be a state of the central nervous system. (...) In fact, as we will see shortly, CSM is an even more sweeping thesis than this formulation of it suggests, since it is not concerned simply with mental states.One prominent defender of CSM, David Armstrong, has maintained that CSM can be established by means of a two-step argument. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:17. HUME AND ABSTRACT GENERAL IDEAS In his discussion of abstract ideas in the Treatise, Hume offers what "...may... be thought... a plain dilemma, that decides concerning the nature of those abstract ideas..." He states the dilemma in these words: The abstract idea of a man represents men of all sizes and all qualities; which 'tis concluded it cannot do, but either by representing at once all possible sizes (...) and all possible qualities, or by representing no particular one at all. Now it having been esteemed absurd to defend the former proposition, as implying an infinite capacity in the mind, it has been commonly infer'd in favour of the latter; and our abstract ideas have been suppos'd to represent no particular degree either of quality or quantity. (T, 1,1,7,?.18) However, with respect to this dilemma, Hume says: But that this inference is erroneous, I shall endeavor to make appear, first, by proving, that 'tis utterly impossible to conceive any quantity or quality, without forming a precise notion of its degrees: And secondly by showing, that tho' the capacity of the mind be not infinite, yet we can at once form a notion of all possible degrees of quantity and quality, in such a manner at least, as, however imperfect, may serve all the purposes of reflexion and conversation. (T, 1,1,7, p. 18) The second item Hume claims he is about to prove is aimed at the first disjunct of the above-stated dilemma; more specifically, it is aimed at the claim that (1) An abstract idea (e.g., of a man) represents all possible degrees of quantity and quality (in men) only if the human mind is infinite in capacity. To show that (1) is false, Hume offers his own positive account of how ideas which are particular in nature may nevertheless be general in representation, even though the mind's capacity is finite. The first item Hume sets out to prove is aimed at the second disjunct, and conclusion, of the dilemma; it is aimed, that is, at 18. (2)Abstract ideas represent no particular degree of either quantity or quality. In this paper I will be concerned solely with Hume's attack on (2); it is this attack in which Hume says I "place my chief confidence." (T, I, I, 7, p. 24) I_ As stated, (2) is ambiguous, since it might be taken to mean that abstract ideas fail to represent altogether, or that they fail to represent any quantity or quality however construed. But, I believe, Hume means neither of these; he means, instead, that (2a) Abstract ideas represent non-particular, indeterminate degrees of quantity or quality. Now recall that Hume tries to refute (2a) by establishing, as he says, that (3)It is impossible to conceive any quantity or quality without forming a precise notion of its degrees. But how, by establishing (3), would Hume thereby refute or aid in the refutation of (2a)? And, for that matter, how does he support (3)? Hume's case for (3) consists of three arguments, the respective conclusions of which are most pertinent here. He concludes his first argument by saying that (4)...the general idea of a line...has in its appearance in the mind a precise degree of quantity and quality. (T, 1,1,7, p. 19) The conclusion of the second argument is this : (5)An idea is a weaker impression; and as a strong impression must necessarily have a determinate quantity and quality, the case must be the same with its copy or representative.(T, 1,1,7, p. 19) 19. and of the third it is this: (6)Abstract ideas are therefore in themselves individual, however they may become general in their representation. The image in the mind is only that of a particular object, tho' the application of it in our reasoning be the same, as if it were universal.(T, 1,1,7, p. 20) Construed in a fully general way, these conclusions assert that (7)Each idea is determinate with respect to öegree of) quantity and quality. But notice that (7) is not equivalent to, and does not obviously imply, (3). Hence, Hume... (shrink)

This fourth edition of one of the classic logic textbooks has been thoroughly revised by John Burgess. The aim is to increase the pedagogical value of the book for the core market of students of philosophy and for students of mathematics and computer science as well. This book has become a classic because of its accessibility to students without a mathematical background, and because it covers not simply the staple topics of an intermediate logic course such as Godel's Incompleteness Theorems, (...) but also a large number of optional topics from Turing's theory of computability to Ramsey's theorem. John Burgess has now enhanced the book by adding a selection of problems at the end of each chapter, and by reorganising and rewriting chapters to make them more independent of each other and thus to increase the range of options available to instructors as to what to cover and what to defer. (shrink)

George S. Counts was a_ _major figure in American education for almost fifty years. Republication of this early work draws special attention to Counts’s role as a social and political activist. Three particular themes make the book noteworthy because of their importance in Counts’s plan for change as well as for their continuing contem­porary importance: _ _Counts’s crit­icism of child-centered progressives; _ _the role Counts assigns to teachers in achieving educational and social re­form; and Counts’s idea for the re­form (...) of the American economy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Abstract General Ideas in Hume George S. Pappas Hume followed Berkeley in rejecting abstract general ideas; that is, both of these philosophers rejected the view that one could engage in the operation or activity ofabstraction — a kind ofmental separation ofentities that are inseparable in reality —as well as the view that the alleged products of such an activity — ideas which are intrinsically general — really exist. (...) What has not been clear to commentators on either of these two philosophers has been why they each were so opposed to abstraction and abstract general ideas. The provision of an answer to this question is the main thrust of this paper. The nature of the question should be clarified at the outset. I am notasking the psychological question, whatwere BerkeleyandHume's actual intentions when they were moved to reject abstraction and abstract general ideas. Though I regard this question as one of great interest and importance, I am presently aiming to answer a somewhat different one, viz., what role, what philosophical role, does the rejection of abstraction and abstract general ideas play in the philosophies ofBerkeley and Hume? The answer to this latter question is apt to have some bearing on the right way to answer the first question; but, for present purposes, it is important to keep the two questions distinct. The maincontentionofthe paperis thattherejectionofabstraction and abstract general ideas lies at the very heart of the philosophy of Berkeley, and that pretty much the same may be said for Hume. Berkeley's defense ofa kind ofidealism stands or falls with the success ofhis attack on abstract general ideas, and Hume's critique ofinfinite divisibility in matters pertaining to space and time, along with his destructive critique ofvarious metaphysical notions, crucially depends on the successful denial of abstract general ideas. I. Berkeleyan Idealism Berkeley's most extended treatment of abstract ideas comes in the introduction to the Principles ofHuman Knowledge, first published in 1710. However, since he does not take up the topic in any systematic way later in the same book, nor in the Three Dialogues Between Hylas and Phihnous (1713), it has seemed to many commentators that Berkeley's attack on abstract ideas is a local matter, one having only to do with issues concerning language use and a somewhat isolated criticism of Locke. That this is the wrong way to look at things is Volume XV Number 2 339 GEORGE S. PAPPAS perhaps best indicated by a couple of passages from the Principles. In section 5 ofthat work Berkeley says: If we thoroughly examine this tenet it will, perhaps, be found at bottom to depend on the doctrine of abstract ideas. For can there be a nicer strain of abstraction than to distinguish the existence of sensible objects from there being perceived, so as to conceive them existing unperceived? The tenet Berkeley is here referring to is to the effect that sensible objects such as trees and chairs exist independently ofperception. This allusion is made clear when we notice that in the immediately preceding passage Berkeley says: It is indeed an opinion strangely prevailing among men that houses, mountains, rivers, and in a word all sensible objects, have an existence, natural or real, distinct from their being perceived by the understanding. But, with how great an assurance and acquiescence soever this Principle may be entertained... whoever shall find in his heart to call it in question may... perceive it to involve a manifest contradiction. For, what are the aforementioned objects but the things we perceive by sense? and what do we perceive besides our own ideas or sensations? and is it not plainly repugnant that any one of these, or any combination of them, should exist unperceived? (Principles 4) The claim that sensible objects exist independently ofall perception is the very denial of Berkeley's esse is percipi thesis regarding such objects. For the latter thesis holds that each sensible object is such that it exists if and only if it is perceived. So, in the first-quoted passage from Principles 5, Berkeley is saying that the denial of esse is percipi 'depends on' the doctrine of abstract ideas. Surely, the esse is percipi thesis is part ofthe core ofBerkeley's... (shrink)

The natural sciences are sometimes called "hard" sciences in contrast to the social sciences , which are thought to represent "soft" sciences. L. V. Hedges made an important effort to determine the empirical cumulativeness of various scientific research programs, with an eye toward assessing if this criterion is related to a discipline's "hardness" or "softness." This article discusses another criterion, a research program's predictive accuracy, that might also be considered along with a program's empirical cumulativeness. Finally, recent improvements in the (...) predictive accuracy of multifaceted psychological theories are discussed. 2012 APA, all rights reserved). (shrink)

A number of commentators on the work of berkeley have maintained that berkeleyan minds are related to ideas by the relation of inherence. Thus, Ideas are taken to inhere in minds in something like the way that accidents were supposed to inhere in substances for the aristotelian. This inherence account, As I call it, Is spelled out in detail and critically evaluated. Ultimately it is rejected despite its considerable initial plausibility.

Three recently published books, by Stavros Tombazos, Jonathan Martineau, and Harry Harootunian, join a now established body of literature that highlights the temporal aspects of Marx’s work. Their differences notwithstanding, these books are united by the conviction that, at its core, capitalism is an immense and complex organisation of time, and thus that the importance of Marx’s work is realised by its singular contribution to our understanding of this. Each book is centrally concerned with the historically specific character of capital’s (...) temporal order, such that each presents a new reading of the relationship between capitalism and historical time. (shrink)

"Money is plentiful for those who understand the simple laws which govern its acquisition." Read by millions, The Richest Man in Babylon is a classic that offers today's readers a path to success, prosperity, and happiness. Originally published in 1926 as a series of inspirational pamphlets for financial institutions, Clason's work offers financial advice for creating personal wealth using parables set in ancient Babylon. The stories, based on a fictional character, Arkad, are easy to read and packed with priceless wisdom. (...) Offering seven basic principles on saving and investing money, it's often cited as one of the most popular books ever written on the fundamentals of financial success. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Second Copy Thesis in Hume? George S. Pappas The copy thesis which applies to simple ideas andimpressionsin Hume is well known; every simple idea is supposed to be a copy of, that is, to exactly resemble, some simple impression. Or very nearly so, at any rate, for there is the famous missing shade ofblue to take into account. There seems to be another copy thesis in Hume, (...) however, and one on which Hume places a great deal ofweight. We find it expressed early on in the Treatise, incorporated into Hume's discussion of space and time. He says: Wherever ideas are adequate representations of objects, the relations, contradictions and agreements of the ideas are all applicable to the objects; and this we may in general observe to be the foundation of all human knowledge. But our ideas are adequate representations of the most minute parts of extension; and thro' whatever divisions and subdivisions we may suppose these parts to be arriv'd at, they can never become inferior to some ideas, which we form. The plain consequence is, that whatever appears impossible and contradictory upon the comparison of these ideas, must be really impossible and contradictory, without any farther FogeUn has recently described this as a "remarkable passage," one which is "a match for anything found in the writings of the rationalists."2 Perhaps it is such a match, perhaps not, but Fogelin is certainly right to regard this as a remarkable passage, at least for Hume. After all, Hume here seems to be endorsing some form of representationalism, a doctrine we typically do not associate with Hume's philosophy. Two important questions emerge from this passage:just what are these adequate ideas ofwhich Hume speaks; and, in what sense can it be true that they form the foundation ofall ofour knowledge? I believe that a correct answer to each of these questions has some strong imphcations for our understanding ofHume's philosophy. I. Humean Adequate Ideas So far as I can discover, the above-quoted passage is the Only place where Hume talks about adequate ideas. The only text which I have Volume XVII Number 1 51 GEORGE S. PAPPAS found which even suggests the same sentiments occurs in "Of the Passions" where Hume discusses ideas and truth (T 448-49), but no mention is made there of adequate ideas. So I think we have to concentrate on the passage from the Treatise in the attempt to understand what Hume is telling us. Hume seems to refer to adequacy as a feature ofindividual ideas, and also to groups or systems ofideas. The latter is suggested by his reference to relations, contradictions, and agreements between ideas, while the former is indicated by the first clause ofthe quoted passage, where Hume mentions adequacy but makes no reference to relations between ideas. Instead, adequacy in the relationsbetween ideas seems to be a consequence of adequacy of individual ideas. Moreover, that individual ideas are supposed to be adequate is made clear from the argument Hume immediately gives regarding the alleged infinite divisibility of space. He writes: I first take the least idea I can form ofa part ofextension, and beingcertainthatthereis nothingmoreminute than thisidea, I conclude, that whatever I discover by its means must be a real quality ofextension. (T 29) Hume's reasoning here can be interpreted in two different ways, but both rest on the adequacy of individual ideas. He might be read as saying that one starts with a least-sized idea, and infers that there are bits of extension which are the same size as the least-sized idea. The inference from the feature of the idea to the feature of the bit of extension rests on the claimed adequacy ofthe idea. The other reading of Hume's reasoning is that one starts with the least-sized idea and then infers that there is (a) a bit ofextended matter that small, and (b) that there is no smaller bit of extended matter. Ofthese two readings, I think the second is the right way to understand Hume here, for only it supports the argument's conclusion that space is not infinitely divisible.3 But notice that this second version ofHume... (shrink)

In this essay, the author analyses Berkeley’s conformity and inference argument against Locke’s theory of percep tion. Both arguments are not as decisive as traditionally has been perceived and fail to engage in Locke’s actual position. The main reason for this is that Berkeley does not see that Locke’s position is compatible with the non-inferential nature of perceptual knowledge.

Philosophical accounts of perception in the tradition of Kant and Reid have generally supposed that an event of making a judgment is a key element in every perceptual experience. An alternative very austere view regards perception as an event containing nothing judgmental, nor anything conceptual. This account of perception as nonconceptual is discussed first historically as found in the philosophies of Locke and (briefly) Berkeley, and then examined in the contemporary work of Chisholm and Alston.

Most current theories of category-specific semantic deficits appeal to the role of sensory and functional knowledge types in explaining patients' impairments. We discuss why this binary classification is inadequate, point to a more detailed knowledge type taxonomy, and suggest how it may provide insight into the relationships between category-specific semantic deficits and impairments of specific aspects of knowledge.

An attractor network was trained to compute from word form to semantic representations that were based on subject‐generated features. The model was driven largely by higher‐order semantic structure. The network simulated two recent experiments that employed items included in its training set (McRae and Boisvert, 1998). In Simulation 1, short stimulus onset asynchrony priming was demonstrated for semantically similar items. Simulation 2 reproduced subtle effects obtained by varying degree of similarity. Two predictions from the model were then tested on human (...) subjects. In Simulation 3 and Experiment 1, the items from Simulation 1 were reversed, and both the network and subjects showed minimally different priming effects in the two directions. In Experiment 2, consistent with attractor networks but contrary to a key aspect of hierarchical spreading activation accounts priming was determined by featural similarity rather than shared superordinate category. It is concluded that semantic‐similarity priming is due to featural overlap that is a natural consequence of distributed representations of word meaning. (shrink)